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November 6, Sunday
14:00 - 18:00 Check-in & Registration Hotel 3F Lobby
& 7F lobby
18:00 - 20:00 Reception Hotel 7F
banquet room
November 7, Monday
7:30 -  8:45 Breakfast Hotel 3F restaurant
9:00 -  9:10 Teru Ogura (Organizer)
 Opening Remarks & announcements		 Int'l Center 6F
9:10 - 11:10 Oral session 1: Structure-mechanism relationships, Part 1 (Chair: Dale B. Wigley)
9:10 -  9:40  - - - EMBO Plenary Lecture - - -
Paul S. Freemont (Imperial College London, UK)
 Global regulation of protein turnover in mammals: structure, and mechanism of AAA+ ATPase p97
9:40 - 10:10 B. Tracy Nixon (Pennsylvania State University, USA)
 Rigid Body Roll and Ring Asymmetry in the Mechanism of Transcription Activation by Bacterial Enhancer Binding Proteins
10:10 - 10:30 Xiaodong Zhang (Imperial College London, UK)
 Organisations and Regulations of AAA+ Transcriptional Activators at the Enhancer-Binding Sites
10:30 - 10:50 Patricia C. Burrows (Imperial College London, UK)
 A Glutamate Switch Defective Variant of PspF Supports Slow, ATP Inhibited, Remodelling of its Target Transcription Complex
10:50 - 11:10 Majida El Bakkouri (University of Toronto, Canada)
 The Structure of RavA MoxR AAA+ Protein:Design Principles of A Molecular Cage Modulating the Inducible Lysine Decarboxylase Activity
11:10 - 11:40 Coffee Break Int'l Center 6F
11:40 - 13:20 Oral session 2: Structure-mechanism relationships, Part 2 (Chair: Tsutomu Katayama) Int'l Center 6F
11:40 - 12:10 James M Berger (University of California, Berkeley, USA)
 AAA+ proteins involved in DNA replication initiation
12:10 - 12:40 Dale B. Wigley (Institute of Cancer Research, UK)
 Structural and Biochemical Studies of the INO80 Chromatin Remodelling Complex
12:40 - 13:00 Alasdair C. Steven (NIH/NIAMS, USA)
 Bacteriophage Mu Protein MuB Forms a Helical Solenoid in the Presence of DNA: Putative Role in Transposition
13:00 - 13:20 Hidekazu Hiroaki (Nagoya University, Japan)
 Structure and Function of the Two N-Terminal Domains of AAA-ATPases, p60 Katanin and Nuclear Valosin Containing Protein Like 2 (NVL2)
13:20 - 14:50 Lunch & Scientific Committee meeting Int'l Center 6F
14:50 - 17:50 Poster Presentation Int'l Center 6F
  1. Masatoshi Esaki  A ubiquitin-selective AAA chaperone Cdc48p/p97 regulates mitochondrial morphology
  2. * Christopher Wilson  Investigation of the Mechanical Properties of Proteins Using the ClpXP Proteasome
  3. * Patricia C. Burrows  A Glutamate Switch Defective Variant of PspF Supports Slow, ATP Inhibited, Remodelling of its Target Transcription Complex
  4. * Lucy J. Rayner  Chemical Approaches to Understanding a Universal Biomolecular Machine
  5. * Wei Sheng Chia  ATP binding to p97-D1 regulates competition between p47 and Ufd1/Npl4
  6. * Noriko Minami  Regulatory role of cardiolipin in the activity of an ATP-dependent protease, Lon, from Escherichia coli
  7. Takashi Tatsuta  Molecular basis for versatility of the m-AAA protease in mitochondria
  8. * Akinobu Onitake  Regulation of cellular functions of sumoylated proteins by fidgetin
  9. * Takashi Ohgita  Evaluation of the unfolding activity of ClpA from the disruption of Fe-S cluster of Ferredoxin
  10. Yoko Kimura  Dynamics of normal and pathogenic p97/VCP upon mitochondria stress
  11. Majida El Bakkouri  The Structure of RavA MoxR AAA+ Protein:Design Principles of A Molecular Cage Modulating the Inducible Lysine Decarboxylase Activity
  12. * Delia Saffian  Functional and structural analysis of the peroxisomal AAA-type ATPases Pex1p and Pex6p
  13. * Elizabeth A. Sweeny  Conformational changes of Hsp104 revealed through Small Angle X-ray Scattering (SAXS)
  14. * Rie Sawamura  Role of Bcs1p in the respiratory chain complex III assembly
  15. * Kentaro Noi  Observation and characterization of dynamic ATP-dependent movements of p97 AAA ATPase using high-speed atomic force microscopy
  16. Akiko Takaya  YdiV is a novel adaptor protein for ClpXP protease
  17. Shigehiko Tamura  AAA peroxins and their recruiter Pex26p modulate the peroxin interactions involved in peroxisomal protein import
  18. * Yuki Oguchi  Structural dynamics of the hexameric disaggregase ClpB
  19. Hajime Niwa  The N-domain of the mammalian p97 AAA ATPase is necessary for the regulation of ATPase activity
  20. * Skye Hodson  An intricate network of allostery within the E. coli molecular chaperone ClpB coordinates a highly regulated ATPase cycle
  21. * Marta Carroni  Domains location and interactions in the ClpB disaggregase
  22. Hidekazu Hiroaki  Structure and Function of the Two N-Terminal Domains of AAA-ATPases, p60 Katanin and Nuclear Valosin Containing Protein Like 2 (NVL2)
  23. Alan Yueh-Luen Lee  Up-regulation of Mitochondrial Lon AAA+ Protease in Cancer
  24. Shinya Sugimoto  Proteomic survey for Staphylococcus aureus biofilm matrix proteins: extracellular AAA+ chaperone ClpB contributes to the biofilm formation
  25. * John Alexopoulos  Understanding the gating mechanism of ClpP as controlled by the AAA+ proteins ClpA and ClpX
  26. * Morgan E. DeSantis  Inter-subunit Coordination in Hsp104
  27. * Chika Nashiro  Recruiting Mechanism of the AAA Peroxins, Pex1p and Pex6p, to Pex26p on Peroxisomal Membrane
  28. Kenji Keyamura  The Interaction Mode between DnaA and Hda AAA+ Proteins in Regulatory Inactivation of DnaA
  29. * Kazutoshi Kasho  Search and analysis for novel stimulators of DARS2, DnaA-reactivating sequence 2
  30. * Yasunori Noguchi  Role for a residue within AAA+ domain of DnaA protein in stable maintenance of bound nucleotide
  31. Ziqing Mei  Molecular Determinants of MecA as a Degradation Tag for the ClpCP Protease
  32. * Daisuke Morito  Structure and Function of Novel AAA+/Ubiquitin Ligase Mysterin
  33. * Michael Schäkermann  Control of lipopolysaccharide biosynthesis by FtsH-dependent proteolysis of LpxC
  34. * Kai Westphal  Analyzing the extent of FtsH-dependent proteolysis by substrate trapping
  35. Toshiki Tsurimoto  The second PCNA loader Ctf18-RFC interacts with DNA polymerase ε in human cells
  36. Di Xia  Structural and Biochemical Characterizations of IBMPFD Mutants Reveal Functional Principle of Human AAA Chaperone p97
  37. * Tomohiro Shima  Coordination of two heads of cytoplasmic dynein
  38. * Yoshito Kakihara  R2TP Complex Regulates snoRNP/ribosome Biogenesis in Response to Cell Growth Phases and Nutrient Conditions
  39. Kunitoshi Yamanaka  Analysis of CDC-48/p97 on the meiotic chromosome segregation in C. elegans
  40. * Yuki Murayama  Antagonistic control of CDC-48 by C-terminal adaptors UFD-2 and UFD-3 in C. elegans

* Candidates for poster awards
18:00 - 19:30 Dinner Hotel 7F
banquet room
19:40 - 21:20 Oral Session 3: Molecular and cellular functions, Part 1 (Chair: Bernd Bukau) Int'l Center 6F
19:40 - 20:00 Toshiki Tsurimoto (Kyushu University, Japan)
 The second PCNA loader Ctf18-RFC interacts with DNA polymerase epsilon in human cells
20:00 - 20:30 Tsutomu Katayama (Kyushu University, Japan)
 Architecture and mechanism for DNA unwinding of the ATP-DnaA initiation complex of the E. coli chromosomal replication
20:30 - 20:50 Helmut Bergler (Universität Graz, Austria)
 Rlp24 targets the AAA-protein Drg1 to pre-60S particles and stimulates its ATPase activity
20:50 - 21:20  - - - Supported by the Tokyo Biochemical Research Foundation - - -
Walid A. Houry (University of Toronto, Canada)
 The role of the essential helicases Rvb1/2 in snoRNP assembly
22:00 - 24:00 Free discussion Hotel 6F lobby
November 8, Tuesday
7:30 -  8:45 Breakfast Hotel 3F restaurant
9:00 - 10:40 Oral Session 4: Molecular and cellular functions, Part 2 (Chair: R. John Mayer) Int'l Center 6F
9:00 -  9:30 Francis T.F. Tsai (Baylor College of Medicine, USA)
 Structure, function and mechanism of AAA+ machines in protein quality control
9:30 - 10:00  - - - Supported by The Naito Foundation - - -
Bernd Bukau (University of Heidelberg, Germany)
 Mechanism of the Hsp100-Hsp70 bi-chaperone system
10:00 - 10:20 Skye Hodson (University of Bristol, UK)
 An intricate network of allostery within the E. coli molecular chaperone ClpB coordinates a highly regulated ATPase cycle
10:20 - 10:40 Elizabeth A. Sweeny (University of Pennsylvania, USA)
 Conformational changes of Hsp104 revealed through Small Angle X-ray Scattering (SAXS)
10:40 - 11:10 Coffee Break Int'l Center 6F
11:10 - 13:00 Oral Session 5: Molecular and cellular functions, Part 3 (Chair: Walid A. Houry) Int'l Center 6F
11:10 - 11:40 R. John Mayer (University of Nottingham Medical School, UK)
 Proteasomal ATPase interactors: regulators of cellular events as diverse as oncogenesis and neurotransmitter receptor function
11:40 - 12:10 Keiji Tanaka (Tokyo Metropolitan Institute of Medical Science, Japan)
 In-depth structure and biogenesis of eukaryotic proteasomes
12:10 - 12:40 Eilika Weber-Ban (ETH Zurich, Switzerland)
 Pupylation - targeting proteins to the bacterial proteasome
12:40 - 13:00 Daisuke Morito (Kyoto Sangyo University, Japan)
 Structure and Function of Novel AAA+/Ubiquitin Ligase Mysterin
13:00 - 14:30 Lunch Int'l Center 6F
14:30 - 17:50 Oral Session 6: Molecular and cellular functions, Part 4 (Chair: Teru Ogura) Int'l Center 6F
14:30 - 14:50 Axel Mogk (Universität Heidelberg, Germany)
 Function and specificity of the AAA+ protein ClpV in type VI protein secretion
14:50 - 15:10 Feng Wang (Tsinghua University, China)
 Structure and mechanism of the hexameric MecA-ClpC molecular machine
15:10 - 15:30 Joaquin Ortega (McMaster University, Canada)
 Visualizing the ClpX/ClpA Bound State of ClpP Using Acyldepsipeptide Antibiotics
15:30 - 15:50 David A. Dougan (La Trobe University, Australia)
 Regulated protein degradation in bacteria: AAA+ proteases and the adaptor proteins that control them
15:50 - 16:20 Group Photo TBA
16:20 - 16:50 Coffee Break Int'l Center 6F
16:50 - 17:10 Akiko Takaya (Chiba University, Japan)
 YdiV is a novel adaptor protein for ClpXP protease
17:10 - 17:30 Eva Kutejová (Slovak Academy of Sciences, Slovak Republic)
 Protease and Peptidase Activity of the Mitochondrial ATP-dependent Protease Lon can be Separated
17:30 - 17:50 Wataru Sakamoto (Okayama University, Japan)
 The FtsH heterocomplex in chloroplasts and its role in photosynthesis
18:00 - 19:30 Dinner Hotel 7F
banquet room
19:40 - 21:20 Oral Session 7: Molecular and cellular functions, Part 5 (Chair: Ralf Erdmann) Int'l Center 6F
19:40 - 20:00 Takashi Tatsuta (University of Cologne, Germany)
 Molecular basis for versatility of the m-AAA protease in mitochondria
20:00 - 20:30 Phyllis Hanson (Washington University, USA)
 ESCRT-III and VPS4: spiraling toward membrane scission?
20:30 - 21:00 Takashi Hashimoto (Nara Institute of Science and Technology, Japan)
 Katanin is required for generating cortical microtubule arrays in Arabidopsis
21:00 - 21:20 Walter Neupert (Max-Planck-Institut für Biochemie, Germany)
 The AAA-ATPase Bcs1 Mediates a Novel Pathway of Protein Translocation in Mitochondria
22:00 - 24:00 Free discussion Hotel 6F lobby
November 9, Wednesday
7:30 -  8:45 Breakfast Hotel 3F restaurant
9:00 - 10:30 Oral Session 8: Diseases, Part 1 (Chair: Phyllis Hanson) Int'l Center 6F
9:00 -  9:30 Ralf Erdmann (Ruhr-Universität-Bochum, Germany)
 Functional role of the yeast AAA-peroxins Pex1p and Pex6p in peroxisome biogenesis
9:30 - 10:00 Yukio Fujiki (Kyushu University Japan)
 AAA Peroxins, Pex1p and Pex6p, and Their Recruiter Pex26p Modulate the Peroxisomal Targeting Signal 1 (PTS1) Receptor Pex5p in Peroxisomal Protein Import
10:00 - 10:30 Shinji Hirotsune (Osaka City University, Japan)
 Regulation of cytoplasmic dynein: how dynein stops and goes?
10:30 - 11:00 Coffee Break Int'l Center 6F
11:00 - 12:40 Oral session 9: Structure-mechanism relationships, Part 3 (Chair: Yukio Fujiki) Int'l Center 6F
11:00 - 11:30 Takahide Kon (Osaka University, Japan)
 The 2.8-Å crystal structure of the dynein motor domain
11:30 - 11:50 Tomohiro Shima (University of Tokyo, Japan)
 Coordination of two heads of cytoplasmic dynein
11:50 - 12:20 Takashi Ishikawa (Paul Scherrer Institute, Switzerland)
 In situ structural analysis of axonemal dyneins in flagella/cilia by electron cryotomography
12:20 - 12:40 Stephen M. King (University of Connecticut Health Center, USA)
 Functional Architecture of the Outer Arm Dynein Conformational Switch
12:50 - 18:50 Excursion with boxed lunch. For more detail, here.
19:00 - 21:30 Banquet Hotel 7F
banquet room
22:00 - 24:00 Free discussion Hotel 6F lobby
November 10, Thursday
7:30 -  8:45 Breakfast Hotel 3F restaurant
9:00 - 10:50 Oral Session 10: Molecular and cellular functions, Part 6 (Chair: Paul Freemont) Int'l Center 6F
9:00 -  9:30 Jianmin Zhang (John Hopkins University School of Medicine, USA)
 Thorase, a novel AAA+ ATPase, regulates AMPA receptor-dependent synaptic plasticity and behavior
9:30 - 10:00 Hemmo Meyer (University of Duisburg-Essen, Germany)
 A role for the ubiquitin-dependent chaperone VCP/p97 and UBXD1 in protein sorting in the endocytic pathway
10:00 - 10:20 André Franz (University of Cologne, Germany)
 CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication
10:20 - 10:50 Teru Ogura (Kumamoto University, Japan)
 Multiple aspects of multifunctional p97
10:50 - 11:20 Coffee Break Int'l Center 6F
11:20 - 13:20 Oral session 11: Diseases, Part 2 (Chair: Hemmo Meyer) Int'l Center 6F
11:20 - 11:50 Virginia E. Kimonis (University of California-Irvine, USA)
 The R155H VCP Knock-in mouse recapitulates the human disease: varied phenotypes in the dominant and homozygous state
11:50 - 12:10 Di Xia (National Cancer Institute, NIH, USA)
 Structural and Biochemical Characterizations of IBMPFD Mutants Reveal Functional Principle of Human AAA Chaperone p97
12:10 - 12:30 Akira Kakizuka (Kyoto University, Japan)
 Roles of VCP in abnormal phospholipid metabolisms in polyglutamine disease models
12:30 - 12:50 Yoko Kimura (Tokyo Metropolitan Institute of Medical Science, Japan)
 Dynamics of normal and pathogenic p97/VCP upon mitochondria stress
12:50 - 13:20 Louise Bicknell (Western General Hospital, UK)
 Disruption of the pre-replication complex causes growth failure in humans
13:20 - 13:30 Yukio Fujiki (Organizer)
 Closing Remarks
13:30 - 15:00 Lunch Hotel 7F
banquet room
15:00 Departure